Cancer Genes & Pathways
Search a curated gene profile, or move from a mutation to the signalling pathway and evidence that explain its cancer relevance.
Start with the strongest guides
Follow a gene from mutation to pathway to therapy resistance
These linked guides separate gene-level function, pathway-level mechanism, and research interpretation so each page answers a distinct question.
Cornerstone pathway
EGFR signalling in cancer
Receptor activation, RAS–MAPK and PI3K branches, NSCLC mutations, and resistance.
Focused article
EGFR mutations and targeted therapy
A treatment-focused explanation of sensitising mutations, inhibitors, and escape mechanisms.
Gene profile
TP53 function and cancer
A complete, source-linked profile of p53 regulation, checkpoints, mutation effects, and disease context.
Original data report
Which cancer genes appear most often in recruiting trials?
Explore the Oncology Trial Activity Index, see the methodology and download the complete dataset.
Clinical Trials News
A daily, plain-language digest of new oncology and life-sciences clinical trials, with a weekly deep-dive roundup — every update linked to its trial registry or primary source.
Open the newsletter