MTAP Gene Function
Methylthioadenosine Phosphorylase
Overview
MTAP is a metabolic enzyme in the methionine-salvage pathway. Because MTAP lies beside CDKN2A on chromosome 9p21, a single deletion can remove both genes; MTAP loss can alter methylthioadenosine levels and create research interest in PRMT5- and MAT2A-linked dependencies.
Molecular Mechanism
Detailed mechanism data is not yet available for MTAP.
Key Pathways
- ·Methionine salvage
- ·Purine metabolism
- ·PRMT5 dependency
Disease Associations
- ·9p21-deleted cancers
- ·Glioma
- ·Pancreatic cancer
- ·Mesothelioma
Research Activity
MTAP is an actively studied target: about 30+ clinical trials that mention it are currently recruiting on ClinicalTrials.gov. Trial activity reflects research interest, not proven benefit — designs, endpoints and populations vary widely.
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Functional Partners
Common Questions About MTAP
What does MTAP do?
MTAP participates in Methionine salvage, Purine metabolism, PRMT5 dependency. MTAP is a metabolic enzyme in the methionine-salvage pathway. Because MTAP lies beside CDKN2A on chromosome 9p21, a single deletion can remove both genes; MTAP loss can alter methylthioadenosine levels and create research interest in PRMT5- and MAT2A-linked dependencies.
Why is MTAP relevant to cancer research?
Its reported relevance includes 9p21-deleted cancers, Glioma, Pancreatic cancer. The exact alteration, assay and disease context determine what a result can support.