ATRX Gene Function
ATRX Chromatin Remodeler
Overview
ATRX is a chromatin-remodelling protein that helps place histone H3.3 at repetitive regions including telomeres. ATRX loss is associated with alternative lengthening of telomeres in several tumour types, but ATRX status and the ALT phenotype are related rather than interchangeable measurements.
Molecular Mechanism
Detailed mechanism data is not yet available for ATRX.
Key Pathways
- ·H3.3 histone deposition
- ·Telomere maintenance
- ·Chromatin remodelling
Disease Associations
- ·Diffuse glioma
- ·Pancreatic neuroendocrine tumour
- ·ATR-X syndrome
Functional Partners
Common Questions About ATRX
What does ATRX do?
ATRX participates in H3.3 histone deposition, Telomere maintenance, Chromatin remodelling. ATRX is a chromatin-remodelling protein that helps place histone H3.3 at repetitive regions including telomeres. ATRX loss is associated with alternative lengthening of telomeres in several tumour types, but ATRX status and the ALT phenotype are related rather than interchangeable measurements.
Why is ATRX relevant to cancer research?
Its reported relevance includes Diffuse glioma, Pancreatic neuroendocrine tumour, ATR-X syndrome. The exact alteration, assay and disease context determine what a result can support.