DAXX Gene Function
Death Domain Associated Protein
Overview
DAXX works with ATRX as a histone H3.3 chaperone at telomeres and other repetitive DNA. Loss of DAXX can accompany the alternative-lengthening-of-telomeres phenotype, particularly in pancreatic neuroendocrine tumours.
Molecular Mechanism
Detailed mechanism data is not yet available for DAXX.
Key Pathways
- ·H3.3 histone deposition
- ·Telomere maintenance
- ·Chromatin regulation
Disease Associations
- ·Pancreatic neuroendocrine tumour
- ·Alternative-lengthening-of-telomeres cancers
Functional Partners
Common Questions About DAXX
What does DAXX do?
DAXX participates in H3.3 histone deposition, Telomere maintenance, Chromatin regulation. DAXX works with ATRX as a histone H3.3 chaperone at telomeres and other repetitive DNA. Loss of DAXX can accompany the alternative-lengthening-of-telomeres phenotype, particularly in pancreatic neuroendocrine tumours.
Why is DAXX relevant to cancer research?
Its reported relevance includes Pancreatic neuroendocrine tumour, Alternative-lengthening-of-telomeres cancers. The exact alteration, assay and disease context determine what a result can support.