CHEK2 Gene Function
Checkpoint Kinase 2
Overview
CHEK2 is a checkpoint kinase activated downstream of ATM after DNA damage. It can help coordinate cell-cycle arrest, DNA repair and apoptosis; some pathogenic germline variants confer a moderate, context-dependent increase in cancer risk.
Molecular Mechanism
Detailed mechanism data is not yet available for CHEK2.
Key Pathways
- ·DNA-damage response
- ·Cell-cycle checkpoint
- ·p53 signalling
Disease Associations
- ·Hereditary breast cancer susceptibility
- ·Prostate cancer susceptibility
- ·Li-Fraumeni-like cancer families
Functional Partners
Common Questions About CHEK2
What does CHEK2 do?
CHEK2 participates in DNA-damage response, Cell-cycle checkpoint, p53 signalling. CHEK2 is a checkpoint kinase activated downstream of ATM after DNA damage. It can help coordinate cell-cycle arrest, DNA repair and apoptosis; some pathogenic germline variants confer a moderate, context-dependent increase in cancer risk.
Why is CHEK2 relevant to cancer research?
Its reported relevance includes Hereditary breast cancer susceptibility, Prostate cancer susceptibility, Li-Fraumeni-like cancer families. The exact alteration, assay and disease context determine what a result can support.