KMT2D Gene Function
Lysine Methyltransferase 2D
Overview
KMT2D is a chromatin methyltransferase associated with enhancer H3K4 methylation. Loss-of-function alterations can disturb enhancer activity and lineage programmes and are recurrent in lymphoid malignancies and several solid tumours.
Molecular Mechanism
Detailed mechanism data is not yet available for KMT2D.
Key Pathways
- ·H3K4 methylation
- ·Enhancer regulation
- ·Chromatin organisation
Disease Associations
- ·Follicular lymphoma
- ·Diffuse large B-cell lymphoma
- ·Kabuki syndrome
- ·Solid tumours
Functional Partners
Common Questions About KMT2D
What does KMT2D do?
KMT2D participates in H3K4 methylation, Enhancer regulation, Chromatin organisation. KMT2D is a chromatin methyltransferase associated with enhancer H3K4 methylation. Loss-of-function alterations can disturb enhancer activity and lineage programmes and are recurrent in lymphoid malignancies and several solid tumours.
Why is KMT2D relevant to cancer research?
Its reported relevance includes Follicular lymphoma, Diffuse large B-cell lymphoma, Kabuki syndrome. The exact alteration, assay and disease context determine what a result can support.