SMARCB1 Gene Function
SWI/SNF Related Matrix Associated Actin Dependent Regulator Of Chromatin Subfamily B Member 1
Overview
SMARCB1 is a core subunit of the SWI/SNF chromatin-remodelling complex. Biallelic loss is a defining event in malignant rhabdoid tumours and several other rare tumour types, where it disrupts normal enhancer and lineage-control programmes.
Molecular Mechanism
Detailed mechanism data is not yet available for SMARCB1.
Key Pathways
- ·SWI/SNF chromatin remodelling
- ·Enhancer regulation
- ·Lineage control
Disease Associations
- ·Rhabdoid tumour predisposition syndrome
- ·Malignant rhabdoid tumour
- ·Epithelioid sarcoma
Functional Partners
Common Questions About SMARCB1
What does SMARCB1 do?
SMARCB1 participates in SWI/SNF chromatin remodelling, Enhancer regulation, Lineage control. SMARCB1 is a core subunit of the SWI/SNF chromatin-remodelling complex. Biallelic loss is a defining event in malignant rhabdoid tumours and several other rare tumour types, where it disrupts normal enhancer and lineage-control programmes.
Why is SMARCB1 relevant to cancer research?
Its reported relevance includes Rhabdoid tumour predisposition syndrome, Malignant rhabdoid tumour, Epithelioid sarcoma. The exact alteration, assay and disease context determine what a result can support.