Mismatch-Repair Protein Loss Patterns: What IHC Can Show
Mismatch-repair immunohistochemistry assesses protein expression in tumour tissue. Loss patterns can help direct further testing, but they do not by themselves identify the underlying cause or establish Lynch syndrome.
Quick Answer
Mismatch-repair immunohistochemistry assesses protein expression in tumour tissue. Loss patterns can help direct further testing, but they do not by themselves identify the underlying cause or establish Lynch syndrome.
A Protein-Expression Assay
IHC uses staining to assess whether mismatch-repair proteins are detected in tumour cells. Retained staining and loss of staining are technical observations that need pathology-quality controls.
Pattern Is a Starting Point
Protein partners often yield paired patterns, but follow-up may include microsatellite testing, methylation analysis or germline evaluation. The pattern alone is not a diagnosis of inherited disease.
Key Takeaways
- ·IHC assesses protein expression, not DNA sequence.
- ·Loss patterns guide further work-up.
- ·Lynch syndrome requires appropriate confirmatory assessment.
Frequently asked questions
What is the key idea in Mismatch-Repair Protein Loss Patterns: What IHC Can Show?
Mismatch-repair immunohistochemistry assesses protein expression in tumour tissue. Loss patterns can help direct further testing, but they do not by themselves identify the underlying cause or establish Lynch syndrome.
What should be kept with the result or mechanism?
IHC assesses protein expression, not DNA sequence. Loss patterns guide further work-up. Lynch syndrome requires appropriate confirmatory assessment.
References
Continue Reading
DNA Mismatch Repair and Lynch Syndrome
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BRCA1: Homologous Recombination, Inherited Risk and HRD
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