MSH2 Gene Function
MutS Homolog 2
Overview
MSH2 forms mismatch-recognition complexes with MSH6 or MSH3. Loss of MSH2 can disable mismatch repair and cause microsatellite instability; inherited pathogenic variants are associated with Lynch syndrome.
Molecular Mechanism
Detailed mechanism data is not yet available for MSH2.
Key Pathways
- ·DNA mismatch repair
- ·Microsatellite stability
- ·DNA-damage recognition
Disease Associations
- ·Lynch syndrome
- ·Colorectal cancer
- ·Endometrial cancer
- ·Muir–Torre syndrome
Research Activity
MSH2 is an actively studied target: about 30+ clinical trials that mention it are currently recruiting on ClinicalTrials.gov. Trial activity reflects research interest, not proven benefit — designs, endpoints and populations vary widely.
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Functional Partners
Common Questions About MSH2
What does MSH2 do?
MSH2 participates in DNA mismatch repair, Microsatellite stability, DNA-damage recognition. MSH2 forms mismatch-recognition complexes with MSH6 or MSH3. Loss of MSH2 can disable mismatch repair and cause microsatellite instability; inherited pathogenic variants are associated with Lynch syndrome.
Why is MSH2 relevant to cancer research?
Its reported relevance includes Lynch syndrome, Colorectal cancer, Endometrial cancer. The exact alteration, assay and disease context determine what a result can support.