POLE Gene Function
DNA Polymerase Epsilon, Catalytic Subunit
Overview
POLE performs leading-strand DNA synthesis and proofreads newly copied DNA. Pathogenic exonuclease-domain mutations can cause an ultramutated tumour phenotype, while other POLE variants do not necessarily have the same functional consequence.
Molecular Mechanism
Detailed mechanism data is not yet available for POLE.
Key Pathways
- ·DNA replication
- ·Polymerase proofreading
- ·Replication-error repair
Disease Associations
- ·Polymerase-proofreading-associated polyposis
- ·Endometrial cancer
- ·Colorectal cancer
Research Activity
POLE is an actively studied target: about 100+ clinical trials that mention it are currently recruiting on ClinicalTrials.gov. Trial activity reflects research interest, not proven benefit — designs, endpoints and populations vary widely.
Track POLE trials
New and changed oncology trials, summarised in plain language each day.
Functional Partners
Common Questions About POLE
What does POLE do?
POLE participates in DNA replication, Polymerase proofreading, Replication-error repair. POLE performs leading-strand DNA synthesis and proofreads newly copied DNA. Pathogenic exonuclease-domain mutations can cause an ultramutated tumour phenotype, while other POLE variants do not necessarily have the same functional consequence.
Why is POLE relevant to cancer research?
Its reported relevance includes Polymerase-proofreading-associated polyposis, Endometrial cancer, Colorectal cancer. The exact alteration, assay and disease context determine what a result can support.