MUTYH Gene Function
MutY DNA Glycosylase
Overview
MUTYH is a DNA glycosylase in base-excision repair that removes adenines mispaired with oxidised guanine. Biallelic pathogenic germline variants cause MUTYH-associated polyposis, whereas a single pathogenic variant has a different and generally smaller risk implication.
Molecular Mechanism
Detailed mechanism data is not yet available for MUTYH.
Key Pathways
- ·Base-excision repair
- ·Oxidative DNA-damage repair
- ·Genome maintenance
Disease Associations
- ·MUTYH-associated polyposis
- ·Colorectal cancer predisposition
- ·Duodenal polyposis
Functional Partners
Common Questions About MUTYH
What does MUTYH do?
MUTYH participates in Base-excision repair, Oxidative DNA-damage repair, Genome maintenance. MUTYH is a DNA glycosylase in base-excision repair that removes adenines mispaired with oxidised guanine. Biallelic pathogenic germline variants cause MUTYH-associated polyposis, whereas a single pathogenic variant has a different and generally smaller risk implication.
Why is MUTYH relevant to cancer research?
Its reported relevance includes MUTYH-associated polyposis, Colorectal cancer predisposition, Duodenal polyposis. The exact alteration, assay and disease context determine what a result can support.